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348 Similarly, in human chondrocytes stimulated by TNF, GLP-1 analogs (such as liraglutide) showed an anti-catabolic effect, reducing the mRNA expression of MMP-3, MMP-13, and ADAMTS5

Lancet 359 , 824830 (2002)

More serious reactions, though rare, include signs of infection (increasing warmth, redness, swelling, purulent drainage, or fever) or allergic responses (widespread rash, difficulty breathing, or facial swelling)

- [DOI] [PubMed] [Google Scholar] 47.Baggio LL, Drucker DJ

Some participants achieved 20% weight loss when treatment was continued

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